I've been doing some research on the Knoxville Giants. I've gotten some great encouragement and advice from some individuals. And some great leads.
I was looking in the Baseball Digest and came across this issue...
Baseball Digest, Oct.-Nov. 1959
On page 84 of that issue there is a story about Lou Burdette playing a prank on "a certain bubble gum company"...
1957 Topps (card #208)
Here we see Lou Burdette with his glove on his left hand. He's clearly a right handed pitcher.
1958 Topps (card #289)
Again we see Lou Burdette with his glove on his left hand. Again, he's clearly a right handed pitcher.
1959 Topps (card #440)
There are some card organizational sites (Beckett, CheckOutMyCards) that consider this 1964 Topps card to be an uncorrected error. Supposedly he's pitching left handed. Even USA Today mentioned it in a story.
But is it? Where's the evidence to support that? I don't see a glove on either hand. To me it looks like he's just delivered a pitch (even staged) with his right hand. Compare his shoulders to the following card...
1993 Action Packed ASG (card #142)
Again, a staged pose. But you can see the glove on the left hand, therefore a right handed pitcher.
You make the call.